INSUBCONTINENT EXCLUSIVE:
AD is a widely prevalent progressive neurodegenerative disorder marked by memory and cognitive decline, researchers said yet it remains
poorly understood despite decades of dedicated research
As a consequence of this, there are no therapeutics to completely cure the disease, the department of science and technology said in a
process where oxidants attack lipids), reactive oxygen species (ROS), and reduced activity of the antioxidant enzyme glutathione peroxidase
formed by the iron-catalysed reaction of polyunsaturated fatty acids (PUFAs) with ROS to lipid alcohol and as such, acts as a first line of
defence against ferroptosis
neutralising ROS, the potential therapeutic strategies that target GPX4 pathway to alleviate ferroptosis in AD have remained unexplored
GPX4 protein synthesis in itself is an energetically demanding, low efficiency process, and therefore, molecules that can activate and
elevate GPX4 levels might be the key to prevent oxidative stress implicated in chronic disorders.JNCASR scientists present naturally
occurring PPs as innovative and multimodal therapeutic agents with dual capabilities to ameliorate ferroptosis and AD
tissues) and tau protein (abundantly found in the neurons of the central nervous system), diminishing oxidative stress, rescuing
could act as both an activator and enhancer of GPX4
The ability of TA to elevate GPX4 levels even in the presence of AD pathological conditions offers exciting new avenues for targeting novel
study, which steers research toward ferroptosis inhibitors, presents a new dimension for drug development, DST said, adding that this
discovery may inspire medicinal chemists to explore new and derivatives of natural compounds to enhance therapeutic efficacy against
Fe-chelation and antioxidant abilities and singled out tannic acid as a multifunctional molecule exhibiting excellent potencies in all
as a ferroptosis inhibitor acting via both activation and enhancement of GPX4 presents an innovative and holistic strategy against AD
polyphenol, TA as a GPX4 activator that ameliorates A? induced ferroptosis holds great significance and this study presents new
ferroptosis, the research not only addresses specific neurological challenges but also contributes to scientific knowledge, validating new
disease mechanism, global health, and the well-being of dementia patients while inspiring researchers to seek this alternative axis for
therapeutic avenues for neurodegenerative diseases.
